Research

How do genetic and environmental factors interact in human disease?
We need more-diverse biobanks to improve behavioural genetics
He Y & Martin AR. Nature Human Behaviour (2024)
Genetic architecture and socio-environmental risk factors for major depressive disorder in Nepal
Choi KW+, Tubbs J+, Lee H, He Y, et al. Psychological Medicine (2024)
Assessing the genetic contribution of cumulative behavioral factors associated with longitudinal type 2 diabetes risk highlights adiposity and the brain-metabolic axis
Carvalho NRG, He Y, Smadbeck P, et al. medRxiv (2024)
Prediction and stratification of longitudinal risk for chronic obstructive pulmonary disease across smoking behaviors
He Y, Qian DC, Diao JA, et al. Nature Communications (2023)

What are the multi-omic signatures underlying disease heterogeneity across diverse populations?
Multi-trait and multi-ancestry genetic analysis of comorbid lung diseases and traits improves genetic discovery and polygenic risk prediction
He Y, Lu W, Jee YH, et al. medRxiv (2024)

Can we improve medical decision-making for equitable care?
Implications of Race Adjustment in Lung-Function Equations
Diao JA, He Y, Khazanchi R, et al. New England Journal of Medicine (2024)
Aspiring toward equitable benefits from genomic advances to individuals of ancestrally diverse backgrounds
Wang Y+, He Y+, Shi Y, et al. The American Journal of Human Genetics (2024)
Patterns of Undertreatment and Overtreatment in Adjuvant Radiotherapy for Early-Stage Endometrial Cancer Based on Molecular Classification
Ciobanu O, He Y, Martin AR, et al. JAMA Oncology (2024)